How does IPSA carry out the Genetic Infertility testing?

Both the eggs and embryos can be genetically screened to assess particular genetic abnormalities through using advanced genetic techniques. The basic genetic screening method (it has been used successfully for more than 20 years now) is the pre-implantation genetic diagnosis (or PGD). The original use of PGD was to detect/determine any genetic alterations in the embryos of those couples at high risk of passing on some form of the inherited disease to their offspring. These couples, who were usually fertile, needed in-vitro fertilisation (or IVF); their embryos were analysed and some of these embryos were diagnosed as being unaffected by the inherited genetic alteration.

More recently, this PGD technology is being used in IVF treatments for infertile couples, as the technique improves IVF success rates. PGD is used to assess and identify the chromosomally normal IVF embryos to use during the transfer process. The evidence is mounting that both miscarriages and unsuccessful IVF implantations are due to chromosomal imbalances in embryos. Consequently, PGD, which involves egg/embryo screening, is particularly worthwhile if you have had a miscarriage history, unsuccessful IVF cycles, or are older (chromosomal abnormality risk increases with age; e.g., Downs syndrome, when an extra copy of a particular chromosome called chromosome 21 causes the syndrome). Any couple with a previous pregnancy diagnosis involving a chromosome abnormality should consider PGD.

The latest PGD embryo-screening techniques use array comparative genomic hybridisation (called CGH). All of the embryo’s chromosomes can be assessed using CGH, with only low-risk embryos then being selected for embryo transfer.

Please call IPSA Medical Clinic today if you believe you could benefit from Genetic Infertility Testing.

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